Bryan Johnson isn’t just following a strict supplement routine—he’s selling one, too. As part of his Blueprint longevity brand , Johnson has launched a line of supplements that anyone can buy , claiming to offer the same benefits that he carefully tracks in his own anti-aging protocol. From NAD+ boosters to gut health formulas , his supplement line is built around the same principles that drive his extreme approach to longevity: precise dosing, biomarker-based optimization, and a relentless focus on slowing down aging.
But what exactly is he selling, and do his supplements live up to the hype? This breakdown covers the core supplements Bryan Johnson offers , explaining what’s in them, what they claim to do, and whether the science backs it up. If you’re curious about whether his formulas are worth the price , or if you’re just interested in how they compare to other longevity supplements, this guide has everything you need to know.
Let’s dive in.
Longevity Mix Constituent Dosage Potential Risks/Side Effects Half-Life Scientific Rating Longevity Benefits Vitamin C (Ascorbic Acid) 250 mg High doses may cause kidney stones 30 minutes Strong Antioxidant, immune support Calcium (from CaAKG) 400 mg Excess may cause calcification Several hours Moderate Supports bone & cellular function Magnesium (as Magnesium Citrate) 150 mg Can cause diarrhea in high doses 4-6 hours Strong Supports nerve & muscle function Creatine (as Monohydrate) 2500 mg May increase creatinine, use cautiously in kidney disease 3 hours Strong Supports muscle growth & cognition Calcium Alpha-Keto Glutarate (CaAKG) 2000 mg Potential calcium buildup risk Variable Emerging Potential mitochondrial & aging support Taurine 1500 mg Rare allergic reactions 6-8 hours Strong Cardiovascular health Glycine 1200 mg High doses may increase oxalates Variable Moderate Supports cognition & longevity L-Lysine (as HCI) 1000 mg No major risks 2-3 hours Strong Tissue repair & anti-aging Glucosamine Sulfate (as KCI) 750 mg Mild digestive issues Several hours Moderate Joint health & longevity L-Glutathione Reduced 250 mg Rare allergic reactions 1-2 hours Emerging Detoxification & antioxidant L-Theanine 200 mg Can cause drowsiness 4-6 hours Strong Stress reduction & cognitive longevity Sodium Hyaluronate 120 mg No major risks 8-12 hours Moderate Skin & joint longevity
Essential Capsules Constituent Dosage Potential Risks/Side Effects Half-Life Scientific Rating Longevity Benefits Vitamin D (as Cholecalciferol) 50 mcg (2000 IU) Excess may increase calcium buildup 15 hours Strong Supports immune system & longevity Vitamin E (d-alpha-Tocopherol) 67 mg High doses may thin blood 48 hours Strong Antioxidant for longevity Thiamin (Vitamin B1) 1.1 mg Generally safe Variable Strong Supports metabolism & energy Riboflavin (Vitamin B2) 1.4 mg No major risks Variable Strong Energy production & cellular health Niacin (as Niacinamide) 15 mg Flushing, liver stress at high doses 1 hour Strong Supports heart & brain function Vitamin B6 (as Pyridoxine HCI) 1.4 mg Excess may cause neuropathy 5 hours Strong Brain & nerve longevity Folate (as L-5 MethylTetraHydroFolate) 200 mcg Can mask B12 deficiency Variable Strong Supports DNA repair & cell health Vitamin B12 (as Methylcobalamin) 125 mcg High blood levels linked to kidney stress Up to 24 hours Strong Brain longevity Biotin 50 mcg Rare allergic reactions Variable Moderate Supports hair & skin longevity Pantothenic Acid (D-Calcium Pantothenate) 6 mg Generally safe Variable Strong Supports cellular metabolism Calcium (Carbonate & Dicalcium Phosphate) 50 mg High doses may contribute to kidney stones Variable Strong Bone & longevity health Iodine (as Potassium Iodide) 200 mcg Can interfere with thyroid function Variable Moderate Thyroid function Zinc (as Bisglycinate) 15 mg Excess may cause copper deficiency Variable Strong Immune support & longevity Selenium (as L-Selenomethionine) 28 mcg Excess may cause toxicity Variable Strong Antioxidant & longevity support Manganese (as Citrate) 1 mg No major risks Several hours Moderate Supports enzymatic longevity Nicotinamide Riboside (as Chloride) 300 mg May impact kidney fibrosis 6 hours Strong Cellular aging & energy support Broccoli Seed Extract 200 mg Generally safe 8-12 hours Strong Supports detox & aging Fisetin (from Smoke Tree Extract) 100 mg No major risks 6 hours Emerging Senolytic, longevity potential Luteolin (from S. Japonica Extract) 100 mg Potential senolytic effects unknown 8 hours Strong Anti-inflammatory longevity support Ubiquinol (CoQ10) 50 mg No major risks 24 hours Strong Mitochondrial longevity support
Essential Softgel Constituent Dosage Potential Risks/Side Effects Half-Life Scientific Rating Longevity Benefits Vitamin K1 (as Phytonadione) 1500 mcg Excess may lead to blood clotting 24 hours Strong Bone & heart longevity Lutein (from Marigold Flower Extract) 15 mg No major risks 48 hours Strong Eye & skin longevity Lycopene 15 mg No major risks 24 hours Strong Heart health longevity Astaxanthin (Haematococcus Pluvialis) 12 mg No major risks Up to 24 hours Strong Anti-inflammatory longevity support Vitamin K2 MK4 5 mg No major risks Up to 24 hours Strong Cardiovascular longevity Zeaxanthin (from Marigold) 3 mg No major risks 48 hours Strong Eye health & longevity Vitamin K2 MK7 600 mcg No major risks 48 hours Strong Bone & cardiovascular longevity
NAC + Ginger + Curcumin Constituent Dosage Potential Risks/Side Effects Half-Life Scientific Rating Longevity Benefits N-Acetyl-Cysteine (NAC) 1200 mg Can increase oxalates, kidney stone risk 1-2 hours Strong Detox & longevity Ginger Extract 400 mg No major risks Variable Strong Supports inflammation & digestion Curcumin Extract 250 mg No major risks Variable Strong Anti-inflammatory longevity support
Red Yeast Rice + Garlic Constituent Dosage Potential Risks/Side Effects Half-Life Scientific Rating Longevity Benefits Red Yeast Rice Extract 500 mg Can cause muscle breakdown in rare cases Up to 24 hours Strong Supports cholesterol & longevity Odorless Garlic Extract 100 mg May thin blood, interact with anticoagulants 12 hours Strong Cardiovascular longevity
Marko is the founder and editor of LifeSpan Digest. With a deep interest in biotech, healthspan optimization, and regenerative medicine, he analyzes emerging discoveries and explores how science is reshaping human aging. Through expert insights and data-driven reporting, he provides readers with the knowledge to stay ahead in the rapidly evolving field of longevity.
